Myasthenia Gravis

Introduction

Myasthenia Gravis is a autoimmune disorder which is caused due to the development of antibodies which block the receptors in the nervous and muscle junction and cause fatigue in the muscles. Mostly the muscles of eye, face and swallowing are affected. If we look at the neuromuscular junction, the release of Acetylcholine from the neurons binds with the receptor in the muscle junction and the function is carried out. In myasthenia gravis the receptors are blocked thus the Acetylcholine cannot bind with receptors and the muscle function becomes weak.

Symptoms

Eye

Due to the weakness of muscle of eyes there might we weakness in eye and double vision. Eyes cannot be opened properly.

Eating

The food cannot be swallowed properly or the food is left in mouth.

Head and neck

Due to weakness of the muscle of facial expressions and muscles of mastication, there may be facial expressions manifesting as inability to hold the mouth closed (hanging jaw)

Treatment

It mainly includes the drugs which are Acetylcholinesterase inhibitors like neostigmine, Azathioprine. These drugs help to increase the Acetylcholine enzyme in the junction and decrease the break down of this enzyme helping to return to normal stateof the body.

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